Glial activation profile in the spinal cord.

Abstract

<p><i>Astrocytes</i>. The effect of repeated treatment with PEA (30 mg kg^-1 daily i.p.) was evaluated in oxaliplatin-treated rats on day 21. The number of GFAP-positive cells was measured in the dorsal horn of the spinal cord. Images (original magnification 20X) of sections of lumbar spinal cord of oxaliplatin-treated animals (oxaliplatin + vehicle) are reproduced in comparison with control (vehicle + vehicle). Representative immunohistochemical staining after PEA treatments is shown (20X). Each value represents the mean of 12 rats per group, performed in two different experimental sets. *P<0.05 versus vehicle + vehicle; ^P<0.05 versus oxaliplatin + vehicle.</p