<p><b>A.</b> IHC shows decreased baseline levels of p65 subunit of NF-κB in <i>Iqgap2</i><sup><i>-/-</i></sup> colon compared to WT (panels a, d). While DSS treatment resulted in elevated levels of p65 in WT colon, it failed to elicit the same response in <i>Iqgap2</i><sup><i>-/-</i></sup> colon (panel b, e). Termination of DSS treatment results in a restoration of the baseline p65 levels within 7 days in both genotypes (panel c, f). <b>B.</b> IHC of TLR4 in WT and <i>Iqgap2</i><sup><i>-/-</i></sup> colons before and after DSS treatment. <b>C.</b> IHC of MyD88 in the same samples. Note low levels of both TLR4 and MyD88 in <i>Iqgap2</i><sup><i>-/-</i></sup> colons after DSS exposure (panels d). A representative image of N = 5 per genotype is shown for each IHC. Magnification is 200 X.</p
