Microtubule Polymerization in the Presence of Paclitaxel and Derivatives with αβII and αβIII.

Abstract

<p>Isotypically pure bovine brain tubulin (αβII or αβIII) at 1.4 mg/ml was incubated in the presence of drugs and the absorbance at 350 nm was measured every 8 seconds for at least 11 minutes. The concentration of each drug was 10 μM. PTX is paclitaxel.</p