Representative Ca²⁺ responses of TSCs from T1r3 KO mice.

Abstract

<p>Stimuli tested were IMP (1mM), 4 different L-amino acids (MPG (10mM), Ser (20mM), Arg (10mM), and Gln (10mM)), and L-amino acids with IMP. [A] Ca²⁺ responses of 2 sample TSCs. Each cell was tested with all 9 stimuli. The responses of these cells are examples of some of the different response patterns elicited by the array of stimuli. The bar above each stimulus trace represents the stimulus application time (30 sec). [B] Mean±SEM amplitude of Ca²⁺ increase (ΔF%) above baseline for responsive cells only, i.e. only cells with a change in baseline Ca²⁺≥5%. Numbers in parenthesis are the number of cells.</p