Manganese-Catalyzed
Aerobic Oxytrifluoromethylation
of Styrene Derivatives Using CF<sub>3</sub>SO<sub>2</sub>Na as the
Trifluoromethyl Source
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Abstract
A mild
and practical protocol for manganese-catalyzed aerobic oxytrifluoromethylation
of olefinic bonds of styrene derivatives using CF<sub>3</sub>SO<sub>2</sub>Na (Langlois’ reagent) as the CF<sub>3</sub> source
is described. A distinguishing feature of this method is the generation
of trifluoromethyl radicals from CF<sub>3</sub>SO<sub>2</sub>Na using
the simple manganese salt/O<sub>2</sub> system. The reaction proceeds
under ambient conditions, free of added peroxide initiators, and provides
moderate to good selectivities for alcohol versus ketone product
