Effects of adipose-derived stem cells (ASCs) on lung inflammation and goblet cell hyperplasia.

Abstract

<p>ASCs treatment decreased the infiltration of eosinophils and PAS-positive cells around the airway and blood vessel in asthmatic mice (H&E, PAS ×200). Blocking PGE2 (A) or TGF-β (B) eliminated the beneficial effect of ASCs on lung inflammation and goblet cell hyperplasia. Data are expressed as the mean ± SEM of four independent experiments each performed in triplicate. *,§,ǁ,**,§§,ǁǁ <i>p</i><0.001, † <i>p =</i> 0.020, ‡ <i>p</i> = 0.024, ¶ <i>p</i> = 0.003, †† <i>p =</i> 0.030, ‡‡ <i>p</i> = 0.035, ¶¶ <i>p</i> = 0.005.</p