Rhodium-Catalyzed Alkylation of C–H Bonds in Aromatic Amides with Styrenes via Bidentate–Chelation Assistance

Abstract

Rhodium-catalyzed alkylation reactions of aromatic C–H bonds in aromatic amides with styrene derivatives have been developed by using an 8-aminoquinoline as a bidentate directing group. C–C bond formation selectively occurred between the <i>ortho</i> C–H bonds in aromatic amides and the terminal carbon of the styrene derivatives. The presence of an 8-aminoquinoline moiety is essential for the success of the reaction

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