Long-term impact of vaccination on onchocerciasis annual transmission potential and microfilarial load in the absence of ivermectin treatment under different assumptions of initial vaccine efficacy.
<p><b>A:</b> Model assumes an initial vaccine efficacy against the development of incoming worms of 50% and against skin microfilarial load of 90%. <b>B:</b> Model assumes a higher initial vaccine efficacy against the development of incoming worms of 70% and against skin microfilarial load of 95%. Results assume mean duration of prophylactic and therapeutic effects of 20 years (rate of decay = 0.05 per year) and an 80% coverage of vaccination. Annual transmission potential (ATP): the average number of L3 larvae potentially received per person per year.</p><p>Long-term impact of vaccination on onchocerciasis annual transmission potential and microfilarial load in the absence of ivermectin treatment under different assumptions of initial vaccine efficacy.</p
