Leukemic invasion of KOBA cells induces distinctive effects on the gene expression and phenotypes of ECs and MCs in BM.

Abstract

<p>(<b>a</b>) ECs and MCs were sorted from the BM of mice 14 days after KOBA cell inoculation, and the expression of indicated genes was determined with quantitative RT-PCR. The means and SEs from three mice are shown. <i>P</i> < 0.05. (<b>b</b>) The surface expression of indicated molecules was analyzed with multi-color FACS in the CD31⁺ (EC) and PDGFRβ⁺ (MC) cell gates before (black line) and 14 days after (red line) KOBA inoculation. Shaded areas indicate control staining.</p