RNase treatment reduced cognitive impairment induced by unilateral nephrectomy surgery in aged mice.

Abstract

<p>The MWM was used for the training of spatial memory formation in aged mice for 7 days before experiments and followed by the postoperative testing of reversal learning for 7 days. A, Escape latency during the experiments. B, Percentage of time spent in the target quadrant during the experiments. C, Swimming path length during the experiments. D, Swimming speed during the experiments. E, The probe trial test at day 3 and day 7 after surgery. F, Representative swim paths for S-R and S-P group at day 3 after surgery. The above data are shown as mean ± SEM; n = 10 for training; n = 8 for testing. *<i>P</i><0.05 v.s. S-S group, #<i>P</i><0.05 v.s. S-R group. S-S, sham surgery plus placebo; S-P, surgery plus placebo; S-R, surgery plus RNase.</p