RNase treatment decreased cytokine expression in the hippocampus and serum after unilateral nephrectomy in aged mice.

Abstract

<p>A, Hippocampal cytokine mRNA. At day 1, day 3 and day 7 after surgery, cytokine mRNA levels were measured using qRT-PCR. B, Serum cytokine protein expression. At day 1, day 3 and day 7 after surgery, cytokine proteins were assayed using Luminex. Data are presented as mean ± SEM (panel A, n = 4 per group; panel B, n = 6 per group). *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001, ****<i>P</i><0.0001. CXCL1, chemokine (C-X-C mortif) ligand 1; MIP-2, macrophage inflammatory protein-2; MCP-1, monocyte chemotactic protein-1; IL, interleukin; TNF, tumor necrosis factor; S-S, sham surgery plus placebo; S-P, surgery plus placebo; S-R, surgery plus RNase.</p