The α<sub>2B</sub>AR dependent hypertensive response is enhanced in arrestin 3 deficient mice.
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Abstract
<p>(A) Mean arterial pressure (MAP) measured in Arr3<sup>-/-</sup>and corresponding Arr3<sup>+/+</sup> mice in the same genetic background after injection of UK14,304 (0.1mg/kg i.v.). (B) Quantitation of agonist-induced changes in MAP(ΔMAP) over the basal level. (C) Quantitation of area under curve of the hypertensive response curve. n = 5 for each group. *, <i>p</i> <0.05, Arr3<sup>+/+</sup><i>vs</i>. Arr3<sup>-/-</sup>.</p