Large size ratio (LSR) of CNVs from leukocytes from prostate cancer patients are correlated with aggressive behavior of prostate cancer.

Abstract

<p>(A) Schematic diagram of LSR model of leukocyte CNV. (B) LSRs from leukocytes are associated with aggressive prostate cancer recurrence behavior. Upper panel: Correlation of LSRs from leukocyte genomes with prostate cancers that were recurrent; Lower panel: Correlation of LSRs from leukocyte genomes with prostate cancers that were non-recurrent 90 months after radical prostatectomy. (C) LSRs from leukocytes are associated with short PSADT. Upper panel: Correlation of LSRs from leukocyte genomes with prostate cancers that had recurrent serum prostate specific antigen doubling time (PSADT) 4 months or less; Lower panel: Correlation of LSRs from leukocyte genomes with prostate cancers that were not recurrent or recurrent but having PSADT 15 months or more.</p