IRI results in a transient cholestasis and altered biliary physiology.
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Abstract
<p><b>(A)</b> Partial hepatic ischaemia model with bile duct isolation (Left). Schematic representation of groups in both studies (Right). (<b>B)</b> Comparison of bile flow rates (normalised to total body weight). (<b>C)</b> Comparison of serum bile acid concentration between the IRI and sham IRI groups. (<b>D)</b> TEM images comparing BEC microvilli morphology during early (day 1) and late (day 28) reperfusion timepoints. Data are the mean and standard deviation from 3 separate animals at each time point and treatment, *Significantly different compared to sham IRI group, p<0.05.</p