PXR activation reduces IRI-induced fibrosiss in the liver.

Abstract

<p><b>(A)</b> Liver sections stained with Sirius red stain, typical views from the indicated treatment group at the indicated time point after clamp release (scale bar represents 100μm), with (<b>B)</b>, corresponding stain quantification. (<b>C-D)</b> qRT-PCR analysis for TGF-β1 and Col1A1 mRNA transcripts. Data are the mean and standard deviation from 5 separate animals at each time point and treatment, *Significantly different compared to IRI + vehicle group, p<0.05.</p