ER stress inhibitors ameliorated TiPs-induced mouse calvarial osteolysis and osteoclastogenesis.

Abstract

<p>(A) Representative micro-CT with three-dimensional reconstructed images from each group. (B and C) Bone volume/total volume (BV/TV) and percentage of total porosity of each sample were measured. (D) Toluidine blue staining of calvaria derived from each group. Scale bar, 1mm. (E) Bone resorption of calvaria (%) in (D). (F) Histochemical staining with TRAP of calvaria derived from each group. Scale bar, 25 μm. Data are presented as the mean± S.E.M. n = 7 mice per group. *P < 0.05, **P < 0.01 versus sham; #P<0.05, ##P<0.01 versus TiPs group.</p

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