Genes with consistent differential expression in the DCN group relative to the Sham group.

Abstract

<p>*Gene exhibits high relative expression in the pineal gland (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137548#pone.0137548.s010" target="_blank">S2 Table</a>).</p><p>^†Gene has previously been found to be differentially expressed between day and night conditions in microarray experiments (adjusted-p < 0.05).</p><p>^‡Gene has strong (FC > 4 or FC < 0.25) and statistically significant (adjusted-p < 0.001) differential expression in the Control and/or Sham night/day <i>in vivo</i> analyses (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137548#pone.0137548.t001" target="_blank">Table 1</a>).</p><p>^§Gene has strong and statistically significant differential expression in either or both of the treated vs untreated <i>in vitro</i> analyses (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137548#pone.0137548.t003" target="_blank">Table 3</a>).</p><p>These genes displayed significant (adjusted-p < 0.001) differentials across 2 analyses: DCN-day vs Sham-day and DCN-night vs Sham-night. Genes are classified by the least-extreme fold change across both analyses. The complete results for these analyses are available in the SI (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137548#pone.0137548.s003" target="_blank">S2 Dataset</a>).</p