Abstract

<p>(A-B) There was a main effect of Day (F<sub>1,25</sub> = 4.994, p = 0.035). There was no effect of Treatment or Day x Treatment interaction. (C) <i>t</i>-tests were used to compare distance travelled on Day 1 between the 2.4% nicotine/PG exposed mice and each of the other two groups. Mice exposed to 2.4% nicotine/PG travelled significantly greater total distances than mice exposed to 0% nicotine/PG (t<sub>19</sub> = 2.205, p<0.04) and tended to travel a greater distance than mice exposed to room air (t<sub>13</sub> = 1.857, p<0.09). (D) Rearing behavior was significantly increased in mice exposed to 2.4% nicotine/PG compared to the other groups. This was confirmed in a significant main effect of Treatment (F<sub>1,25</sub> = 7.438, p = 0.003) in the absence of an effect of Day or Day x Treatment interaction. Analysis of each individual day revealed mice exposed to 2.4% nicotine/PG had a greater number of rears than mice exposed to 0% nicotine/PG on both days (t test p<0.0001, Day1; p<0.007, Day 2), and also a greater number of rears than mice exposed to room air on Day 1 (p<0.008). (n = 7–13)</p

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