SPECT/CT images of MDA-MB-231 and A549 tumors by targeting MT1-MMP.
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Abstract
<p>(A) Static planar images of MDA-MB-231 tumor-bearing mice model and A549 tumor-bearing mice model after administration of 11.1 MBq/kg of [<sup>99m</sup>Tc](HYNIC-AF7P)(tricine)(TPPTS) at 0.5 and 2 h post injection. Excess amount (200 μg) of free AF7P was injected for blocking test. (B) Quantification of [<sup>99m</sup>Tc](HYNIC-AF7P)(tricine)(TPPTS) and [<sup>99m</sup>Tc](HYNIC-AF7P)(tricine)(TPPTS) (Blocking) in MDA-MB-231 tumor-bearing mice. Quantification of [<sup>99m</sup>Tc](HYNIC-AF7P)(tricine)(TPPTS) in A549 tumor-bearing mice. ROIs are shown as mean %ID/g ± SD.</p