Abstract

<p><b>(A)</b> Endothelial cells were exposed to D<sub>3</sub> or its metabolites for 24 hours and lysates were probed for VDR transcription targets FOX01 and CYP24. Endothelial cells were exposed to D<sub>3</sub> or its metabolites in the presence of inhibitors of transcription (actinomycin D) and translation (cycloheximide) <b>(B, C)</b> and were assessed for transendothelial resistance or VDR target gene expression. All graphs depict mean ± SEM. * denotes P<0.05, and **** denotes P<0.0001. ### denotes P<0.001, and #### denotes P<0.0001 versus the respective control.</p

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