Application of “Hydrogen-Bonding Interaction” in Drug Design. Part 2: Design, Synthesis, and Structure–Activity Relationships of Thiophosphoramide Derivatives as Novel Antiviral and Antifungal Agents

Abstract

On the basis of the structure of natural product harmine, lead compound <b>18</b>, and the structure of compounds in part 1, a series of thiophosphoramide derivatives <b>1</b>–<b>17</b> were designed and synthesized from various amines in one step. Their antiviral and antifungal activities were evaluated. Most of the compounds showed significantly higher antiviral activity against tobacco mosaic virus (TMV) than commercial virucide ribavirin. Compound (<i>R</i>,<i>R</i>)-<b>17</b> showed the best anti-TMV activity <i>in vitro</i> (70%/500 μg/mL and 33%/100 μg/mL) and <i>in vivo</i> (inactivation effect, 68%/500 μg/mL and 30%/100 μg/mL; curative effect, 64%/500 μg/mL and 31%/100 μg/mL; protection effect, 66%/500 μg/mL and 31%/100 μg/mL), which is higher than that of ningnanmycin and lead compound <b>18</b>. The antiviral activity of (<i>R</i>,<i>R</i>)-<b>17</b>·HCl is about similar to that of (<i>R</i>,<i>R</i>)-<b>17</b>. However, the antifungal activity of (<i>R</i>,<i>R</i>)-<b>17</b>·HCl against Puccinia sorghi is slightly lower than that of (<i>R</i>,<i>R</i>)-<b>17</b>. The systematic study provides compelling evidence that these simple thiophosphoramide compounds could become efficient antiviral and antifungal agents

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