Naringin inhibited collagen production and renal interstitial fibrosis.
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Abstract
<p>(A) The collagen deposition and renal interstitial fibrosis was observed by Masson’s staining(200×). The percentages of fibrosis area were shown. (B) The expression of collagen I in kidney tissues was determined by immunohistochemical staining(400×). (C) The expressions of collagen I, MMP-2, TIMP-1 and TGF-β1 in kidney tissues were detected by western blot. Results represent three independent experiments. Data were expressed as means ± SD, n = 6.<sup>a-c</sup> Means with different superscripts are significantly different (P< 0.05).</p