Principal component analysis (PCA) and orthogonal partial least square discriminant (OPLS-DA) analysis of metabolite changes in GCs and MCs after HCO<sub>3</sub><sup>-</sup> treatment.

Abstract

<p>PCA was performed using four replicate data of relative metabolite abundances in the cell-types at 0, 5, 15, 30, 60, 120 mpi, and the generated PC1 and PC2 were plotted. PCA of two cell-types showing a clear separation of the two groups based on the 268 metabolites for the effect of treatments in (<b>A</b>) GCs, and (<b>B</b>) MCs. The effects of only <b>(C)</b> time and both (<b>D</b>) ‘treatment x time’ were displayed. In OPLS-DA, the metabolite changes as a result of interactions among ‘cell-type x treatment x time were displayed in <b>(E)</b> GCs and (<b>F</b>) MCs.</p

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