<p>The total phenolic, flavonoid and tannin contents in leaf extracts of <i>Calibrachoa x hybrida</i> (<i>C.h.</i>) (Solanaceae) international cultivars, as well as their overall antioxidant activities using DPPH and linoleic acid assays, were investigated. Furthermore, the antifungal and the antibacterial activities were examined against a wide spectrum of micro-organisms. DPPH and linoleic acid assays ranged from 62.1 to 80.1% and of 74.1–93.4%, respectively. <i>C.h</i>. Superbells® Trailing Rose (CHST), <i>C.h.</i> Superbells® Frost Fire, <i>C.h</i>. Superbells® Strawberry Punch, <i>C.h</i>. Superbells® Dreamsicle and <i>C.h.</i> Superbells® Plum (CHSP) varied in their antifungal and the antibacterial activities against a wide spectrum of micro-organisms. CHSP exhibited the highest antioxidant, antifungal and antibacterial activities followed by CHST. These activities might be attributed to the presence of phenolic, flavonoid and tannin compounds, indicating that these cultivars might be potential sources of therapeutic substances.</p
