Biocompatible Nanoparticles of KGd(H<sub>2</sub>O)<sub>2</sub>[Fe(CN)<sub>6</sub>]·H<sub>2</sub>O with Extremely High <i>T</i><sub>1</sub>‑Weighted Relaxivity Owing to Two Water Molecules Directly Bound to the Gd(III) Center
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Abstract
A simple one-step method for preparing
biocompatible nanoparticles of gadolinium ferrocyanide coordination
polymer KGd(H<sub>2</sub>O)<sub>2</sub>[Fe(CN)<sub>6</sub>]·H<sub>2</sub>O is reported. The crystal structure of this coordination
polymer is determined by X-ray powder diffraction using the bulk materials.
The stability, cytotoxicity, cellular uptake, and MR phantom and cellular
imaging studies suggest that this coordination-polymer structural
platform offers a unique opportunity for developing the next generation
of <i>T</i><sub>1</sub>-weighted contrast agents with high
relaxivity as cellular MR probes for biological receptors or markers.
Such high-relaxivity MR probes may hold potential in the study of
molecular events and may be used for in vivo MR imaging in biomedical
research and clinical applications
