Yb(OTf)<sub>3</sub>‑Mediated
Access to Furans
from β‑Ketothioamides via Eschenmoser Sulfide Contraction
Reaction
- Publication date
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Abstract
A mild and straightforward synthetic
protocol for construction
of a furan skeleton promoted by Yb(OTf)<sub>3</sub> from β-ketothioamides
and arylglyoxals has been developed at room temperature. Importantly,
this protocol involves a tandem sequence that includes aldol condensation,
N-cyclization, ring opening, O-cyclization, S-cyclization, and Eschenmoser
sulfide contraction