Histamine is reduced in <i>cart</i>^<i>1</i> mutant photoreceptor neurons.

Abstract

<p>Histamine was immunolabeled in horizontal sections of heads from (A-B) wild type (wt: <i>w</i>^<i>1118</i>) and (C-D) <i>cart</i>^<i>1</i> mutant flies. (A) Strong signals in the lamina neuropile (La) and R7/R8 terminals in the distal medulla (Me) were detected in control <i>w</i>^<i>1118</i>. Additional immunolabel also appeared from cells in the lobula (Lo) (arrowhead). (B) The enlarged image of the wt head section in (A). Arrowheads in the lamina and medulla identified histamine positive photoreceptor terminals. (C) Loss of photoreceptor histamine signals and strong signals in lamina marginal glia were detected in <i>cart</i>^<i>1</i> mutant. (D) The enlarged image of the <i>cart</i>^<i>1</i> head section in (C) showing labeled marginal glia (arrow) but no photoreceptor signals. Scale bars: 50μm</p