Modified Method for Measuring the Solubility of Pharmaceutical
Compounds in Organic Solvents by Visual Camera
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Abstract
A modified synthetic method with
a high definition visual camera
technique for measuring the solubility of solutes in solvents or mixed
solvents was proposed. To verify the reliability of the experimental
apparatus, the solubility of NH<sub>4</sub>Cl in water was determined
at different temperatures. The relative standard errors were less
than 1%, compared to the literature data. The solubilities of betulonic
acid in six organic solvents from (278.15 to 313.15) K were measured
and correlated with the Apelblat equation and universal quasichemical
equation, respectively. The modified method was quite concise and
user-friendly, and made the process of dissolution to become visualized
and automatic
