<p>Immunized W/W<sup>v</sup> and +/+ mice were challenged 7 times with OVA or saline, as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146686#pone.0146686.g001" target="_blank">Fig 1</a>. Six hours after the last challenge (day 43), the number of sneezes evoked by histamine (A), the accumulation of lymphocytes, neutrophils, and eosinophils in NALF (B), and the antigen-specific serum IgE levels were examined (C). Data are expressed as mean ± SEM for 4–9 animals. *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001, compared with saline-challenged control mice (Mann-Whitney <i>U</i> test).</p
