Abstract

<p><b>(A)</b> Analysis of HO-1 mRNA levels in kidneys from TG and WT mice after UUO. <b>(B)</b> Representative immunofluorescence images of kidney sections co-labeled with HO-1 (red) and E-cadherin (green) in the Sham and UUO groups on day 7. (Magnification, ×200; bars = 250 μm) White stars indicate glomerulus. <b>(C)</b> Graph showing the area of HO-1 staining. <b>(D)</b> Representative immunofluorescence images of kidney sections co-labeled with HO-1 (red) and F4/80 (green) in the WT and TG groups at 7 day after UUO. (Magnification, ×400; bars = 125μm) (E) Representative higher magnifications views of dual immunostaining with HO-1 (red) and F4/80 (green) after UUO. (Magnification, ×1000; bars = 50 μm). (F-H) Line graphs indicating that there were no differences in body weight (F) before surgery or in serum creatinine levels (G) or proteinuria (H) after sham or UUO surgery between the WT and TG groups. * P<0.05, ** P<0.01, *** P<0.001 vs. WT mice of the Sham group; <sup>&</sup>P<0.05, <sup>&&</sup>P<0.01 vs. TG mice of the Sham group; #P<0.05, ## P<0.01, ### P<0.001 vs. WT mice of the respective groups.</p

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