Mechanically induced Aβ binding and dissociation.

Abstract

<p>(A) is a representative experimental force plot: the tip approaches the sample (red line) and when it touches the surface—the cantilever bends (steep linear region). The two surface-bound monomers are allowed to bind (red to blue transition at top of linear region. The cantilever retracts (blue steep linear region). As the cantilever returns to its neutral position, the force plot passes through the base line. At this point the system is in its minimum free energy state (B). The cantilever is not deflected and the system resembles a stable dimeric state (B). As the cantilever retracts, a mechanical force is applied along the reaction coordinate and the free energy of the system increases (E). The system reaches its maximum free energy just prior to rupture at x = x<sub>β</sub> (E) at which point the cantilever is at its maximum deflection (C). At dissociation, the cantilever returns to its neutral position (D) and all free energy of the system is lost [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0147488#pone.0147488.ref040" target="_blank">40</a>].</p

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