In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. As a result of fitting to the proposed model, aCBV values in gray matter  were in good agreement with those from literature

Ki Hwan Kim (1660372)

Seung Hong Choi (107291)

Sung-Hong Park (679800)

PLoS ONE

PubMed

Raw data of the Figures and Tables in the paper

Ki Hwan Kim (427869)

, Seung Hong Choi (1421602)

The Francis Crick Institute

Feasibility of quantifying arterial cerebral blood volume using multiphase alternate ascending/descending directional navigation (ALADDIN)

Arterial cerebral blood volume (aCBV) is associated with many physiologic and pathologic conditions. Recently, multiphase balanced steady state free precession (bSSFP) readout was introduced to measure labeled blood signals in the arterial compartment, based on the fact that signal difference between labeled and unlabeled blood decreases with the number of RF pulses that is affected by blood velocity. In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. A new kinetic model considering bSSFP RF perturbations was proposed to describe the multiphase data and thus to quantify aCBV. Since the inter-slice time delay (TD) and gap affected the distribution of labeled blood spins in the arterial and tissue compartments, we performed the experiments with two TDs (0 and 500 ms) and two gaps (300% and 450% of slice thickness) to evaluate their roles in quantifying aCBV. Comparison studies using our technique and an existing method termed arterial volume using arterial spin tagging (AVAST) were also separately performed in five subjects. At 300% gap or 500-ms TD, significant tissue perfusion signals were demonstrated, while tissue perfusion signals were minimized and arterial signals were maximized at 450% gap and 0-ms TD. ALADDIN has an advantage of visualizing bi-directional flow effects (ascending/descending) in a single experiment. Labeling efficiency (α) of inter-slice blood flow effects could be measured in the superior sagittal sinus (SSS) (20.8±3.7%.) and was used for aCBV quantification. As a result of fitting to the proposed model, aCBV values in gray matter (1.4-2.3 mL/100 mL) were in good agreement with those from literature. Our technique showed high correlation with AVAST, especially when arterial signals were accentuated (i.e., when TD = 0 ms) (r = 0.53). The bi-directional perfusion imaging with multiphase ALADDIN approach can be an alternative to existing techniques for quantification of aCBV

Ki Hwan Kim

Seung Hong Choi

Sung-Hong Park

Directory of Open Access Journals

Feasibility of Quantifying Arterial Cerebral Blood Volume Using Multiphase Alternate Ascending/Descending Directional Navigation (ALADDIN).

In this study, we evaluated the feasibility of a new 2D
inter-slice bSSFP-based arterial
spin labeling (ASL) technique termed,
alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in
six healthy subjects. As a result of fitting to the proposed model, aCBV
values in gray matter (1.4
– 2.3 mL/100 mL) were in good agreement with those from literature.





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Crossref

Feasibility of Quantifying Arterial Cerebral Blood Volume Using Multiphase Alternate Ascending/Descending Directional Navigation (ALADDIN)

https://figshare.com/articles/Feasibility_of_quantifying_arterial_cerebral_blood_volume_using_multiphase_alternate_ascending_descending_directional_navigation_ALADDIN_/2069743

Feasibility of quantifying arterial cerebral blood volume using multiphase alternate ascending/descending directional navigation (ALADDIN)

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The Francis Crick Institute

Directory of Open Access Journals

The Francis Crick Institute

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