Structure of Mixed-Monolayer-Protected Nanoparticles
in Aqueous Salt Solution from Atomistic Molecular Dynamics Simulations
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Abstract
Gold nanoparticles
(AuNPs) protected by a grafted ligand monolayer
are commonly used for applications in biosensing, bioimaging, and
drug delivery, in part because of the ability to tune surface properties
by modifying the composition of the protecting ligands. If the surface
monolayer contains multiple distinct ligand species, the AuNPs are
referred to as mixed-monolayer-protected particles. A typical mixed
monolayer consists of two linear alkanethiol ligands, with one ligand
species end-functionalized to confer aqueous solubility. However,
the inclusion of multiple ligand species raises questions of how the
nanoscale morphology and the relative lengths of the two ligands can
affect properties, considerations that are unnecessary for single-component
monolayers. In this work, we use atomistic molecular dynamics simulations
to model the structure of mixed-monolayer-protected AuNPs in aqueous
salt solution under typical biological conditions. We focus on identifying
changes in the monolayer structure as a function of the diameter of
the AuNP core, the morphology of the protecting ligands, and the relative
ligand length, complementing existing studies of homogeneous monolayers.
Our results show that increasing the particle diameter strongly inhibits
ligand fluctuations, consistent with a reduction in free volume associated
with higher-curvature substrates. We also show that, in aqueous solution,
particles with striped, mixed, and random morphologies exhibit similar
behaviors, as ligand fluctuations mask any influence of the grafting
positions. Finally, our simulations indicate that long hydrophobic
ligands always deform to allow shorter hydrophilic ligands to access
water, leading to a significant distortion of the interface if the
hydrophobic ligands are much longer than the hydrophilic ones. Our
results thus provide new physical insight into the structure of mixed-monolayer-protected
particles under typical biological conditions and can be used to guide
the experimental design of new classes of AuNPs for biological applications