Cooperative Catalytic
Reactions Using Organocatalysts
and Transition Metal Catalysts: Propargylic Allylation of Propargylic
Alcohols with α,β-Unsaturated Aldehydes
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Abstract
Propargylic allylation of propargylic alcohols with α,β-unsaturated
aldehydes in the presence of a thiolate-bridged diruthenium complex
and a secondary amine as cocatalysts has been found to give the corresponding
propargylic allylated products, where the γ-propargylation occurs
selectively at the α,β-unsaturated aldehydes, in high
yields as a mixture of two diastereoisomers