Multidimensional scaling (MDS) analysis of gene expression data.

Abstract

<p>MDS analysis based on all commonly detected genes shows that samples segregate by diagnosis (A) and not by storage condition (B). Distances correspond to leading log-fold-changes between each pair of samples. MDS based on differentially expressed genes demonstrates less within-group variance compared to MDS with all detected genes in the RNAlater^® (C) and FFPE (D) datasets. <i>NF</i>: <i>Normal</i>, <i>FFPE; NR</i>: <i>Normal</i>, <i>RNAlater</i>^<i>®</i><i>; TF</i>: <i>Tumor</i>, <i>FFPE; TR</i>: <i>Tumor</i>, <i>RNAlater</i>^<i>®</i>. <i>NO = Normal; TU = Tumor</i>.</p