Development of a candidate marker for ccRCC.

Abstract

<p>(A) Expression values of <i>CA9</i> correctly classified 30 of 32 samples in our FFPE dataset. (B) Whisker plot of expression value distribution in our FFPE dataset for <i>CA9</i>. (C) Scatterplot for the expression values of <i>CA9</i> in our FFPE and in our RNAlater dataset. (D) <i>CA9</i> expression values correctly classify 139 out of 144 samples in a microarray dataset of ccRCC (GSE53757). (E) Distribution of <i>CA9</i> expression values for normal (NO) and ccRCC tumor samples (TU) in the GSE53757 dataset. (F) Stratification of the expression values of overexpressed <i>CA9</i> into all four stages of ccRCC [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149743#pone.0149743.ref014" target="_blank">14</a>].</p