Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates
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Abstract
A rapid allylic fluorination method utilizing trichloroacetimidates in conjunction with an iridium catalyst has been developed. The reaction is conducted at room temperature under ambient air and relies on Et<sub>3</sub>N·3HF reagent to provide branched allylic fluorides with complete regioselectivity. This high-yielding reaction can be conducted on a multigram scale and shows considerable functional group tolerance. The use of [<sup>18</sup>F]KF·Kryptofix allowed <sup>18</sup>F<sup>–</sup> incorporation in 10 min