Comparison of AOX1 and choline oxidase active sites.

Abstract

<p>AOX1 monomer is colored as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149846#pone.0149846.g002" target="_blank">Fig 2C</a>, the CO is colored grey. The residues delimiting the substrate binding cavity are labeled and represented as sticks. Modified a-FAD is depicted in ball-and-stick representation. (a) The active site of AOX1 with cavities depicted in atom colored surface representation. The substrate binding cavity is marked with blurred red rim. The water molecule, which is bound close to the isoalloxazine ring, is depicted as sphere. Polar interactions are marked as dashed lines. (b) The active site of Choline oxidase with cavities depicted in surface representation. The substrate binding cavity is marked with blurred red rim. (c) Cartoon representation of superimposed AOX1 and Choline Oxidase monomers.</p

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