The Schematic diagram shows that the R1628P genetic mutation of LRRK2 provide a potential “two-hit” target of environment toxic MPP+-induced Cdk5 activation, and Cdk5 could phosphorylate the adjacent amino residue S1627 of R1628P mutation, thus activate LRRK2 kinase activity and cause neuronal death.
<p>The Schematic diagram shows that the R1628P genetic mutation of LRRK2 provide a potential “two-hit” target of environment toxic MPP+-induced Cdk5 activation, and Cdk5 could phosphorylate the adjacent amino residue S1627 of R1628P mutation, thus activate LRRK2 kinase activity and cause neuronal death.</p
