Single Fluzone vaccination with or without adjuvants is non-protective in aged mice.

Abstract

<p>Young adult (6–8 weeks) and aged (18–24 months) C57/BL6 mice (n = 5–8 mice per group) were vaccinated with Fluzone (FZ), Fluzone+CpG (FZ+CpG) or left unvaccinated as controls. Approximately 4 weeks later, all groups were challenged with 1x10⁴ p.f.u of A/California/09 H1N1 virus. Weight loss (A) and (C) and survival (B) and (D) were monitored daily in young adult and aged mice respectively. Individual data points represent average weight loss within the group of surviving mice +/-SEM.</p