Transient effects on incidence of combining transgenic vector manipulation with antimicrobial medications of varying efficacies.

Abstract

<p>(A-B) results for transgenic manipulation aimed at population replacement. (C-D) The same analysis for the case when transgenic manipulation aims at population reduction. Panel (A) assumes <i>α</i> = 10⁻²; panel (B) assumes <i>ρ</i> = (<i>U</i>^⋆ + <i>V</i>^⋆). Panels (B, D) assume an additional medication-induced recovery rate that is 10% of the natural recovery rate for all simulations, but vary <i>α</i> (B) or the time <i>τ</i>_<i>m</i> until releases stop (D). The vertical dotted-dashed line represents the point in time where resistance arises or releases end.</p