Tuning of Copper-Catalyzed Multicomponent Reactions
toward 3‑Functionalized Oxindoles
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Abstract
A tunable
copper-catalyzed azide–alkyne cycloaddition (CuAAC)-initiated
multicomponent reaction strategy for the construction of 3-functionalized
indolin-2-ones is reported. Upon controlling the ring opening of four-membered <i>O</i>-heterocyclic intermediates, this unique method enables
the divergent derivatization of <i>N</i>-protected isatins
to give three-component (3-CR) and four-component (4-CR) adducts,
respectively