Anti-inflammatory and Quinone Reductase Inducing Compounds
from Fermented Noni (<i>Morinda citrifolia</i>) Juice Exudates
- Publication date
- Publisher
Abstract
A new fatty acid ester disaccharide,
2-<i>O</i>-(β-d-glucopyranosyl)-1-<i>O</i>-(2<i>E</i>,4<i>Z</i>,7<i>Z</i>)-deca-2,4,7-trienoyl-β-d-glucopyranose (<b>1</b>), a new ascorbic acid derivative, 2-caffeoyl-3-ketohexulofuranosonic
acid γ-lactone (<b>2</b>), and a new iridoid glycoside,
10-dimethoxyfermiloside (<b>3</b>), were isolated along with
13
known compounds (<b>4</b>–<b>16</b>) from fermented
noni fruit juice (<i>Morinda citrifolia</i>). The structures
of the new compounds, together with <b>4</b> and <b>5</b>, were determined by 1D and 2D NMR experiments, as well as comparison
with published values. Compounds <b>2</b> and <b>7</b> showed moderate inhibitory activities in a TNF-α-induced NF-κB
assay, and compounds <b>4</b> and <b>6</b> exhibited considerable
quinone reductase-1 (QR1) inducing effects