Direct Construction of 2‑Aryliminochromenes from Arynes, <i>N</i>,<i>S</i>‑Keteneacetals, and DMF

Abstract

A concise and direct synthetic strategy for the construction of 2-aryliminochromene skeleton by cascade three-component coupling reaction of arynes, <i>N</i>,<i>S</i>-keteneacetals, and DMF in good yields has been disclosed. The process demonstrates the first example of aryne chemistry combined with <i>N</i>,<i>S</i>-keteneacetals. Using this strategy, an expeditious synthesis of biologically important arylimino-2<i>H</i>-chromene-3- carboxamides was achieved

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