Transition Metal Free Intermolecular Direct Oxidative C–N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant

Abstract

Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C–N bond formation of allylic C­(sp<sup>3</sup>)–H and vinylic C­(sp<sup>2</sup>)–H of allyllic compounds with amidines using O<sub>2</sub> as the sole oxidant. This protocol features protecting group free nitrogen sources, good functional group tolerance, high atom economy, and environmental advantages

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