Transition Metal Free Intermolecular Direct Oxidative
C–N Bond Formation to Polysubstituted Pyrimidines Using Molecular
Oxygen as the Sole Oxidant
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Abstract
Various polysubstituted
pyrimidines are smoothly formed via a base-promoted
intermolecular oxidation C–N bond formation of allylic C(sp<sup>3</sup>)–H and vinylic C(sp<sup>2</sup>)–H of allyllic
compounds with amidines using O<sub>2</sub> as the sole oxidant. This
protocol features protecting group free nitrogen sources, good functional
group tolerance, high atom economy, and environmental advantages