<div><p>Purpose</p><p>To elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury.</p><p>Methods</p><p>A cross-sectional questionnaire survey was performed online by scanning a Quickmark (QR) code with smartphones at the 20<sup>th</sup> Chinese National Conference of Ocular Trauma in November 2014.</p><p>Results</p><p>A total of 153 (30.6%) of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56.9% were used only in cases with high risk of endophthalmitis development. The intraocular route of delivery was mainly included with intracameral injection (47.9%) and intravitreal injection (42.0%). Cephalosporins (53.8%) and vancomycin (42.0%) were the main choices of antibiotic agents, followed by fluoroquinolones (24.3%), and aminoglycosides (13.4%). Only 21.9% preferred a combination of two or more two drugs routinely. In addition, significantly more respondents from the referral eye hospital (92.7%) replied using intraocular antibiotics injection for prophylaxis compared to those respondents from the primary hospital (69.4%) (<i>p</i> = 0.001, Fisher’s exact test).</p><p>Conclusions</p><p>Intraocular antibiotics injection for post-traumatic endophthalmitis prophylaxis is widely used in China. However, the choice of antibiotic agents and the intraocular route of delivery vary. A well-designed clinical trial is needed to establish a standardized protocol of intraocular antibiotics administration for post-traumatic endophthalmitis prophylaxis.</p></div
