Rational Design of Multi-Stimuli-Responsive Nanoparticles
for Precise Cancer Therapy
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Abstract
Stimuli-responsive nanoparticles
with target capacity are of great
interest in drug delivery for cancer therapy. However, the challenge
is to achieve highly smart release with precise spatiotemporal control
for cancer therapy. Herein, we report the preparation and properties
of multi-stimuli-responsive nanoparticles through the co-assembly
of a 3-arm star quaterpolymer with a near-infrared (NIR) photothermal
agent and chemotherapeutic compound. The nanoparticles can exhibit
NIR light/pH/reduction–responsive drug release and intracellular
drug translocation in cancer cells, which further integrate photoinduced
hyperthermia for synergistic anticancer efficiency, thereby leading
to tumor ablation without tumor regrowth. Thus, this rational design
of nanoparticles with multiple responsiveness represents a versatile
strategy to provide smart drug delivery paradigms for cancer therapy
