<p><b>A</b>) Plotting each individual’s time course of serum AFP relative to diagnosis an elevation in values is observed prior to diagnosis. Here all individuals in the HCC review in whom AFP influenced clinical management (n = 49) are charted with AFP on a log<sub>10</sub> scale. <b>B</b>) Graphic demonstrates the concept of gradient and intercept over a specific individual’s time course. <b>C</b>) The screening cohort of 1509 patients followed over time for development of HCC, overall incidence at end of index screening (1186 days from 01/01/2009, total HCC free % = 93.7).</p
