<p>a) Rat. Distal Metaphysis of Femur. (H&E. 200x). Replacing normal trabecular architecture are poorly differentiated neoplastic cells that are polygonal to spindle shaped with lightly eosinophilic cytoplasm. b) Rat. Distal Metaphysis of Femur. (H&E. 400x). Neoplastic cells are irregularly polygonal with indistinct cell borders and moderate amounts of cytoplasm. Nuclei contain multiple, distinct nucleoli and a mitotic figure is present (asterisk).</p

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