Exit of BMMNC from the heart after IC injection.

Abstract

<p>After IC injection of three different doses (1, 8, 40×10⁶) of rat BMMNC in to rat hearts using the Langendorff <i>ex-vivo</i> perfusion model, the numbers of BMMNC in the coronary effluent in every minute were counted. The majority of BMMNC injected exited from the heart into coronary effluent in 1 minute after IC injection of any cell dose studied. The pattern of cells exited from the heart did not differ between the doses (n = 8 different hearts studied in each dose, <i>p>0</i>.<i>99</i>, Two-way repeated measure ANOVA). Upper panel for 1×10⁶ BMMNC injection; Middle panel for 8×10⁶ BMMNC injection; Lower panel for 40×10⁶ BMMNC injection.</p